14/06/2016 Biology Engineering Medicine
DOI: 10.1016/j.jbiomech.2016.04.027 SemanticScholar ID: 24994986 MAG: 2381273044

In-vitro investigation of cerebral-perfusion effects of a rotary blood pump installed in the descending aorta.

Publication Summary

This study describes use of a cardiovascular simulator to replicate the hemodynamic responses of the cerebrovascular system with a mechanical circulatory support device operating in the descending aorta. To do so, a cerebral autoregulation unit was developed which replicates the dilation and constriction of the native cerebrovascular resistance system and thereby regulates the cerebral flow rate within defined limits. The efficacy of the replicated autoregulation mechanism was investigated by introducing a number of step alterations in mean aortic pressure and monitoring the cerebral flow. The steady responses of the cerebral flow to changes in mean aortic pressure were in good agreement with clinical data. Next, a rotary pump, modeling a mechanical circulatory support device, was installed in the descending aorta and the hemodynamic responses of the cerebral system were investigated over a wide range of pump operating conditions. Insertion of a mechanical circulatory support device in the descending aorta presented an improved cardiac output as a result of afterload reduction. It was observed that the primary drop in cerebral flow, caused by the pump in the descending aorta, was compensated over the course of five seconds due to a gradual decrease in cerebrovascular resistance. The experimental results suggest that the implantation of a mechanical circulatory support device in the descending aorta, a less invasive procedure than typical mechanical circulatory support implantation, will not have an adverse effect on the cognitive function, provided that the cerebral autoregulation is largely unimpaired.

CAER Authors

Avatar Image for Eldad Avital

Dr. Eldad Avital

Queen Mary University of London - Reader in Computational (& Experimental) Fluids and Acoustics

Share this

Next publication

2009 Psychology

The Dynamics of Category Conjunctions

R. Hutter, R. Crisp, G. Humphreys, Gillian. M. Waters + 1 more