16/10/2009 Medicine Psychology
DOI: 10.1186/1472-6963-9-188 SemanticScholar ID: 11303594 MAG: 2100788683

Collaborative Depression Trial (CADET): multi-centre randomised controlled trial of collaborative care for depression – study protocol

Publication Summary

Comprising of both organisational and patient level components, is a potentially powerful intervention for improving depression treatment in UK primary Care. However, as previous models have been developed and evaluated in the United States, it is necessary to establish the effect of in the UK in order to determine whether this innovative treatment model can replicate benefits for patients outside the US. This Phase III trial was preceded by a Phase II patient level RCT, following the MRC Complex Intervention Framework. A multi-centre controlled trial with cluster-randomised allocation of GP practices. GP practices will be randomised to usual control or to collaborative care - a combination of case manager coordinated support and brief psychological treatment, enhanced specialist and GP communication. The primary outcome will be symptoms of depression as assessed by the PHQ-9. If is demonstrated to be effective we will have evidence to enable the NHS to substantially improve the organisation of depressed patients in primary care, and to assist primary providers to deliver a model of enhanced depression which is both effective and acceptable to patients. ISRCTN32829227

CAER Authors

Avatar Image for Simon Gilbody

Prof. Simon Gilbody

University of York - Director of the Mental Health and Addictions Research Group

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